CRLF3 |
CRLM-3 |
interleukin-11 receptor-alpha |
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[cytokine receptor-like molecule-2] This receptor has been identified originally as a murine expressed sequence tag (EST) showing homology with the erythropoietin receptor. The full-length cDNA encodes a protein of 359 amino acids. CRLM-2 lacks the typical WSXWS motif characteristic of the Type 1 cytokine receptor family. CRLM-2 displays significant homology with the receptors for Erythropoietin, IL2 (receptor beta and gamma), and IL9 (receptor alpha). Differential splicing of the receptor gene generates a variant transcript encoding a soluble form of CRLM-2 (Hiroyama et al, 2000).
CRLM-2 is expressed preferentially in hematopoietic cells
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