Crk-2 |
CRKRLDRN |
GIG18 |
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This peptide, Cys-Arg-Lys-Asp-Lys-Cys, which is similar to a segment in thrombospondin type 1 repeat, has been identifed by Järvinen and Ruoslahti (2007) through phage display library screening as a homing peptide that homes to wounds in mice. Intravenously injected peptide selectively accumulates at wound sites, co-localizing partially with blood vessels. The peptide shows a preference for later stages of wound healing. Kean et al (2012) have used the peptide to coat mesenchymal stem cells. Injection of peptide-coated cells into mice with myocardial infarction improves homing of the stem cells
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