CREG2 |
c-Rel |
ETAPLSTMLSPY |
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This peptide, Cys-Arg-Glu-Lys-Ala, has been identified by in vivo screening of phage-displayed peptide libraries as a tumor homing peptide. The peptide binds to clotted plasma proteins in vitro and, unlike some other tumor homing peptides, recognizes the fibrin / fibronectin complexes in clotted plasma in the tumor stroma and the walls of vessels, which is undetectable in normal tissues. The CREKA peptide fails to accumulate in B16F1 melanomas grown in fibrinogen knock-out mice, which lack the fibrin meshwork in transplanted tumors (Simberg et al, 2007).
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