cpto |
CPXV203 |
CD264 |
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[cowpox virus 012 protein] This protein encoded in the genome of cowpox virus blocks antigen presentation in both human and murine cells and therefore acts as an immunoevasin, hindering viral clearance by cytotoxic T-cells. CPXV012 is a small type 2 transmembrane protein that inhibits antigenic peptide transport from the cytosol to the endoplasmic reticulum by blocking peptide transport by TAP [transporter associated with antigen processing] (Buyn et al, 2009; Alzhanova et al, 2009). Luteijn et al (2014) have reported that CPXV012 prevents the presentation of viral peptides to cytotoxic T-cells by blocking ATP binding to TAP.
For another unrelated viral
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