cpn60 |
CPNGRC |
HHV-8 orfK9 |
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[copine-7] The gene encoding copine-7 has been identified by Savino et al (1999). Oh et al (2015) have reported that the protein is found in the conditioned medium of pre-ameloblasts. It is secreted extracellularly during ameloblast differentiation. The secreted protein translocates to differentiating odontoblasts where it promotes the expression of odontoblastic markers and the expression of Dentin sialophosphoprotein. CPNE7 induces odontoblast differentiation and promotes dentin/pulp-like tissue formation in human dental pulp cells in vivo. CPNE7 also induces the differentiation into odontoblasts of non-dental
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