CP-2
[cycling protein-2] This protein has been identified by Wright et al (1983) as a stage-specific secretory product of the rat seminiferous epithelium. CP-2 shows a pronounced cycle of secretion, its peak at Stage VI being 30-fold greater than at its nadir at Stages XII-XIV, The protein is produced by Sertoli cells (Wright and Luzarraga, 1986). The protein is found also in the kidney, the brain (with greatest concentration in the supraoptic and paraventricular nuclei), and the posterior pituitary (Zabludoff et al, 1990).
Erickson-Lawrence et al (1991) have shown that Cyclic protein-2 is the proenzyme form of cathepsin L.
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