CDT |
CDTA |
Medullary thyroid carcinoma 1 |
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[cornea-derived transcript 6] A cornea-specific gene transcript isolated by differential cDNA hybridization (Peek et al, 1998). The protein encoded by this transcript is related to angiopoietins and is being referred to also as Angiopoietin X (abbr. AngX). The approved gene symbol is ANGPTL7 [angiopoietin-like-7].
CDT6 is a secreted disulfide-linked homotetrameric protein. Within the cornea, expression of CDT6 is confined to the stromal layer. The factor may contribute to the avascularity of the human cornea as a negative regulator of angiogenesis. In a mouse xenograft model expression of CDT6 reduces tumor growth and causes aberrant blood vessel
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