CAMP(134-170) |
CAMPATH-1 |
signal transducer and activator of transcription-2 |
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this antimicrobial peptide has been isolated from human breast milk (Wang et al, 2020). The peptide occurs at higher levels in preterm milk than in term milk.The sequence of CAMP211-225, YPVTQPLAPVHNPIS, corresponds to a bioactive fragment of casein-beta [casein-beta(213-226) or beta-casein(213-226)]. The peptide possesses specific antimicrobial activity against pathogenic Escherichia coli and Yersinia enterocolitica. CAMP211-225 kills bacteria through a membrane-disrupting mechanism, but not by binding to intracellular nucleic acids.
CAMP211-225 administration has been shown to effectively reduce ileal mucosa damage in an experimental mouse
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