CFH |
CFIRNCPKGamide |
VIRIP |
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this term - also C-nociceptors - pertains to peripherally localized small diameter bundles of afferent sensory neurons with unmyelinated axons that are separated from one another by the cytoplasm of unmyelinated Schwann cells, forming what is known as Remak bundles. These fibers show low conduction velocity, and the activation of C-fibers by these stimuli leads to a longer-lasting sensation of pain (for overview see: Woolf and Ma, 2007; Dubin and Patapoutian, 2010). These fibers are said to be polymodal, i.e., they often respond to combinations of thermal, mechanical, and chemical stimuli (Kumazawa T, 1996). See also: A-fibers, some of which are involved also in processing of pain information.
The development of diverse subpopulations of cutaneous C-fibers , including VGLUT3(+) low-threshold c-mechanoreceptors, MrgprD(+) polymodal
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