BAX-inhibiting peptide |
BAX-interacting factor-1 |
armored CAR T-cells |
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abbr. BI-1, BAXI1. Bax inhibitor-1 is a member of a highly preserved protein family that also comprises LFG [Lifeguard], and GAAP [Golgi anti-apoptotic protein]. TMBIM6 [transmembrane BAX inhibitor motif containing 6] the approved gene symbol for BAX inhibitor-1.
Human BAX inhibitor-1 has been identified by virtue of its ability to prevent the activity of the pro-apoptotic protein BAX, which confers a lethal phenotype when expressed in yeast. BAX inhibitor-1 is an evolutionarily conserved integral membrane protein localized predominantly to intracellular membranes. BAX inhibitor-1 can interact with BCL2
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