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BAC1.2F5

A mouse macrophages cell line derived from splenic adherent cells from a (BALB/c X A.CA) F1 mouse and generated by transfection with SV40 DNA mutated in the origin of replication (Schwarzbaum et al, 1984).

BAC1.2F5 cells produce lysozyme, collagenase, and esterase, bear Fc receptors, express Ia antigens, and engage in Fc mediated phagocytosis. The cells can be induced to secrete IL1 into the conditioned medium (Morgan et al, 1987).

The growth of these cells depends upon the presence of the colony stimulating factors M-CSF and ... ... ... ... ... Subscribe to continue reading! ... ...

 

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