B1 cells |
B-1d B-cells |
single-negative cells |
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[B-1 cell]
This term (also: B-1 B-cells) refers to a subset of B-cells (also: B-1 lymphocytes) identified originally in adult mice and found also in humans (Sagaert et al, 2004; Berland and Wortis, 2002; Herzenberg, 2000; Su and Tarakhovsky, 2000; Youinou et al, 1999; Kantor et al, 1992; Martin and Kearney, 2001; Allman and Pillai, 2008). These cells comprise less than 5 % of splenic B-cells (B-2 cells) (For an overview of B-1 cells and different subtypes see also: Aziz et al, 2015).
Using a transgenic system allowing changing B-cell antigen receptor specificity in B-cells in an inducible and programmed manner, Graf et al (2019) have shown that mature
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