B cell-helper neutrophils

abbr. NBH cells. This neutrophil cell type, identified by Puga et al (2011) are found around the marginal zone of the spleen, a B-cell area specialized in T-cell-independent immunoglobulin responses to circulating antigen. These cells, unlike conventional neutrophils, induce IgM secretion by marginal zone B-cells and activate marginal zone B-cells more effectively and more rapidly than follicular naive B-cells through both contact-dependent and contact-independent mechanisms. Splenic neutrophils induce immunoglobulin class switching, somatic hypermutation and antibody production by activating marginal zone B-cells through a mechanism involving the cytokines ... ... ... ...
 
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Entry last modified: January 2022