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Astrostatine

This biochemically uncharacterized 17 kDa protein is found in the conditioned medium of normal neurons. Two neuronal cell lines, the PC12 rat pheocromocytoma and the neuro 2A (N2A) murine neuroblastoma also release such an activity if the cells are at high density and show a low proliferation rate.

The protein inhibits the proliferation of type 1 astrocytes and may play a role in the development of astrogliosis.

Astrostatine does not react with antibodies directed against TGF-beta or EGF receptors.

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