ApoNETosis |
Apopain |
TNFR55 |
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[Apoptogenic Protein 1] This protein is encoded by open reading frame C14orf153 [chromosome 14 open reading frame 153]. The approved gene symbol is APOPT1 [apoptogenic 1, mitochondrial].
This evolutionarily conserved protein (194 amino acids) has been identified by Yasuda et al (2006). Mouse Apop-1 is expressed ubiquitously but at different levels in all mouse organs tested. The gene had been identified originally because its expression was higher in atherosclerotic plaque-derived smooth muscle cells than in nonplaque-derived cells.
Expression of Apop-1 induces cell death by apoptosis by releasing
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