Angiomodulin
abbr. AGM. This factor is secreted by tumor blood vessels (see also: angiogenesis) and is present on the surface of endothelial cells (Akaogi et al, 1996). In cell culture, it promotes cell adhesion and morphological changes to form cord-like structures of the human bladder carcinoma cell line ECV-304. Cord formation is prevented by heparin, which inhibits the binding of Angiomodulin to ECV-304 cells.
Angiomodulin may be involved in angiogenesis and modulation of the vascular functions necessary for tumor development. Expression of angiomodulin in invading tumor cells correlates with poor prognosis in human
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