Aerolysin

aerolysin is a protein of 54 kDa produced by Aeromonas hydrophila (Buckley et al, 1981), a human pathogen that produces deep wound infection and gastroenteritis. The aerA gene encoding aerolysin has been cloned (Chakraborty et al, 1986; Howard and Buckley, 1986; Howard et al, 1987).

The toxin is secreted as an inactive precursor, proaerolysin, that must be proteolytically processed at its C-terminus to become active (Howard and Buckley, 1985; van der Goot et al, 1992). The protoxin is activated by at least three mammalian proprotein convertases (furin, PACE4, and PC5/6A) (Abrami et al, 1998). The protein oligomerizes into stable heptameric structures (Wilmsen et al, 1992; Buckley, 1992; Lesieur et al, 1997) and irreversibly inserts into the plasma membrane where it produces pore-forming channels.

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Entry last modified: September 2003