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Abd-B

[abdominal-B] This Drosophila melanogaster gene (gene: CG11648) is a homeotic gene encoding a sequence-specific transcription factor involved in providing cells with specific positional identities on the anterior-posterior axis. The protein contributes to the maintenance of intersegmental boundaries through the regional activation of apoptosis, which involves direct regulation of the apoptosis activator reaper (Lohmann et al, 2002). Birkholz et al (2013) have reported that Abd-B controls the size and composition of the terminal neuromeres by regulating programmed cell death of several progeny cells within certain neuroblast lineages.

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