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this peptide, termed cardiac targeting peptide (abbr. CTP), has been identified by Zahid et al (2010) as a targeting peptide for cardiomyocytes. Mice injected with the peptide show significant transduction of heart tissue with minimal uptake by lung and kidney capillaries, and no uptake in liver, skeletal muscle, spleen or brain. The peptide acts as cell-penetrating peptide and in a cardiac-specific manner. When fused to NBD (Nemo-binding domain), an 11-amino acid peptide (TALDWSWLQTE) that inhibits activation of the inducible NF-kappa-B Kinase (IKK), pretreatment with this fusion peptide ... ... ... ... ... Subscribe to continue reading! ... ...

 

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