AMELY |
Amercin |
Senescent Cell Anti-apoptotic Pathways |
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[Antiangiogenic metargidin peptide] AMEP is the recombinant human disintegrin domain of the metalloproteinase ADAM15. Trochon-Joseph et al (2004) have shown that this recombinant protein at concentrations of 2-10 microgram/mL, inhibits endothelial cell proliferation and adhesion on the integrin substrates fibronectin, vitronectin, and fibrinogen. At 10 microgram/mL the protein totally abrogates endothelial cell migration and blocks most capillary formation in a three-dimensional fibrin gel. Electrotransfection of an expression plasmid into nude mouse muscle blocks most tumor angiogenesis
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