ADCC

[Antibody-dependent cell-mediated cytotoxicity] ADCC is an antibody-dependent immune reaction mediated by LGL cells (large granular lymphocytes), i.e. killer cells and NK-cell lymphocytes. The ADCC reaction is very sensitive. It plays an important role in hypersensitivity and occurs at antibody concentrations that are well below those leading to complement lysis.

The importance of ADCC in vivo is difficult to evaluate because the activities of NK-cells and also the direct effects of antibodies cannot be separated from the ADCC reaction.

NK-cells play a major role as effector cells in the spontaneous destruction of tumor cells and virus-infected ... ... ... ...
 
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Entry last modified: September 1994