aaMF |
aaMPhi |
Agammaglobulinemia tyrosine kinase |
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(approved gene symbol) [Angio-associated migratory cell protein; Angio-associated migratory protein] The cDNA for AAMP has been isolated from a human melanoma cell line during a search for motility-associated cell surface proteins (see also: Motogenic cytokines).
The sequence of AAMP (52 kDa) contains, among other motifs, an immunoglobulin-like domain and a heparin binding consensus motif (see also: HBGF [heparin binding growth factors]). AAMP is a protein that has been conserved in evolution. The sequence shows a striking evolutionary relationship with the YCR072c protein in Saccharomyces cerevisiae (Beckner et al, 1995).
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