8.2 kDa differentiation factor

This glycosylated factor (54 amino acids as deduced from the cloned cDNA) is purified from the conditioned medium of human myelogenous HL-60 leukemia cells induced by retinoic acid (Kostanyan IA et al, 1994). The factor induces differentiation in HL-60 cells. Northern blot analyses demonstrate that the level of transcripts is higher in differentiated cells than in nondifferentiated cells.

The published sequence of this differentiation factor shows that it is derived from the 83 amino acid RPS21 [ribosomal protein S21] (Bhat and Morrison, 1993). Smirnova et al (2004) have described the factor as ... ... ... ...
 
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Entry last modified: March 2012