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25H11 antigen

This murine antigen, identified by a monoclonal antibody of the same name, represents an integral membrane protein of 47 kDa expressed by cells in the ventricular zone of the anterior and lateral telencephalon. The protein is identical with ephrin B1 (Stuckmann et al, 2001).

Ephrin B1 appears at the onset of neocortical neurogenesis, being first expressed in neuron-generating neuroepithelial cells and rapidly thereafter in virtually all neuroepithelial cells. Expression persists through the period of neocortical neurogenesis and is downregulated thereafter. Expression is detected also on radial glial cells, extending all the way to their pial endfeet, and on neurons ... ... ... ... ... Subscribe to continue reading! ... ...

 

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