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100KF is a vasoactive plasma factor present in the circulation of healthy subjects and patients with minimal change disease, the pathophysiology is characterized glomerular alterations and proteinuria. The partly purified factor is able to affect glomerular extracellular matrix molecules, such as glomerular sialoglycoproteins or glomerular ecto-ATPase in vitro and in vivo (Bakker et al, 1988; Cheung et al, 1996).

Cheung et al (1999) have reported that this biochemically uncharacterized factor may be an isoform of hemopexin, as demonstrated by internal amino acid sequences, reactivities of antibodies against hemopexin and 100KF, and the biological behaviour of hemopexin. Cheung et al, 2000) have reported that human hemopexin ... ... ... ... ... Subscribe to continue reading! ... ...


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